When discussing male reproductive aging, people typically focus on three metrics: testosterone levels, sperm concentration, y DNA fragmentation rate. However, a review article published in February 2026 in the World
Introduction In the functional nutrition industry, the question is no longer "How much active ingredient is included?" but rather "How much can the body actually utilize?" For a highly fragile
Friends working in the NAD⁺ y brain health industries have likely asked themselves the same question: NR (Nicotinamide Riboside) is widely recognized as one of the most effective NAD⁺ precursors. From h
Liposomal NAD⁺ Delivers Up to 30% Greater Transdermal Absorption For years, NAD⁺ has been one of the most talked-about anti-aging ingredients in the skincare industry. Countless brys have invested heavily in developin
En los últimos años, NAD+ se ha convertido sin duda en una de las moléculas más populares en los campos del antienvejecimiento y la longevidad saludable. Desde laboratorios científicos hasta mercados de consumo, las discusiones en torno a ello nunca han cesado.
Aging is being redefined. In 2022, the World Health Organization (WHO) introduced a dedicated code for "aging-related" conditions for the first time in the 11th Revision of the International Classification of
In the long journey against type 2 diabetes, scientists continue to explore new therapeutic strategies. Recently, a study published in the International Journal of Molecular Sciences revealed potential new mechanism
In annual pet health checkups, NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a sensitive marker of myocardial stress. When its levels exceed the normal range, it usually indicates that the heart is under
When it comes to anti-aging, boosting energy, y maintaining vascular health, many people have heard of a specific term—NMN (Nicotinamide Mononucleotide). In recent years, it has garnered significant attention due
The global population is aging at an unprecedented pace. The World Health Organization (WHO) predicts that by 2050, the global population aged 60 y older will exceed 2.1 billion—meaning 1 in every 5 people will b
Recently, NMNH (Reduced $\beta$-Nicotinamide Mononucleotide) has once again sparked widespread attention in the anti-aging field due to newly released human clinical trials. Although both are precursor molecules of
En el campo pionero de la investigación antienvejecimiento, la "familia de las coenzimas" se ha convertido en un tema cyente dentro de la industria. NMN, precursor de NAD+, en su día revolucionó el mundo gracias al respaldo de fi-fi de alto perfil
Long COVID lingers like a persistent shadow, leaving hundreds of millions worldwide struggling with brain fog, fatigue, y insomnia. In November 2025, a team from Harvard Medical School published a 24-week double-blind
En la vida moderna acelerada, el cansancio y el insomnio parecen haberse convertido en "huéspedes frecuentes" para muchas personas. Ante estos problemas, los científicos han descubierto que están relacionados con el agotamiento de un "ene"
La esencia del envejecimiento es una "crisis energética" celular. A medida que los científicos profundizan en la investigación del NAD+, esta coenzima se ha convertido gradualmente en un objetivo central en el campo del antienvejecimiento. Los estudios han encontrado que la dirección
Pérdida de energía, falta de aire al subir escaleras, fluctuaciones de azúcar en sangre postpryiales y cada vez más difícil perder grasa... Estas sensaciones corporales de "envejecer" son realmente un impulsor
In April 2026, China officially released its first national consensus document: the Chinese Expert Consensus on the Role y Clinical Application of NAD⁺ in Aging-Related Diseases (2026 Edition). Led by the Chinese Me
High blood pressure, often called the “silent killer,” is the most important modifiable risk factor for cardiovascular disease. Yet many people face the same frustration: even when taking antihypertensive med
Con el envejecimiento de la población mundial, los cambios degenerativos en el sistema musculoesquelético (como la osteoartritis, la osteoporosis y la sarcopenia) afectan gravemente la calidad de vida de las personas mayores. Piernas temblorosas al caminar, di
When discussing liver health, one fundamental question arises: how can we effectively support this “biochemical factory of the human body” in its complex repair processes when faced with metabolic stress, fat
In the field of anti-aging, NMN (nicotinamide mononucleotide) has long been a highly regarded “star molecule.” As a direct precursor of NAD⁺, it shows great potential in energy metabolism, DNA repair, y ant
In recent years, NAD+ (nicotinamide adenine dinucleotide) has become a highly sought-after “star molecule” in the health y anti-aging field due to its tremendous potential. The most common supplements on th
For a long time, NAD (nicotinamide adenine dinucleotide) has been almost a “styard configuration” in IVD testing. From dehydrogenase reactions to the precise readout of endpoint signals, detection pathways
Parkinson’s disease is not merely about tremors. More concerning is that most patients gradually develop cognitive impairment, which may eventually progress to dementia. Unfortunately, traditional medications can o
How remarkable is the liver’s regenerative ability? Even when two-thirds of a healthy liver is surgically removed, it can restore its original size within just a few weeks. However, under conditions such as disease
En los últimos años, NAD+ ha aparecido frecuentemente en el centro de temas populares como la salud, el antienvejecimiento y la mejora cognitiva. Parece haber dado un salto del laboratorio a la vida cotidiana, convirtiéndose en una nueva favorita
In the vast world of raw materials, some names seem to rise to prominence overnight. Yet in reality, their success is never accidental. NRHM (Nicotinamide Riboside Hydrogen Malate) is one such name—frequently appe
¿Puede una sola molécula en el cuerpo humano convertirse en un motor clave para la salud del corazón? La nicotinamida adenina dinucleótido (NAD+) está emergiendo rápidamente como un foco principal de investigación científica. Como participante principal en los metabolizmos energéticos
En la investigación sobre mecanismos antienvejecimiento, el ribósido de nicotinamida (NR), precursor de NAD⁺, ha atraído gradualmente una atención creciente de instituciones científicas. En septiembre de 2023, se obtuvo una patente nacional de invención relacionada con
Cuyo hablamos de salud, el intestino suele estar en el centro de la discusión. No solo es responsable de la digestión y la absorción de nutrientes, sino que también representa el órgano inmunitario más grye del cuerpo humano. En los últimos sí,
In the fields of anti-aging, cellular energy, y biotechnology, the term “NAD⁺” has almost been elevated to a mythical status. Yet, when people come across NAD⁺-related products, many still find themsel
Age is typically defined as the length of time since birth. However, a person’s true physical condition y degree of aging are better reflected by their biological age rather than the number of years they have liv
A medida que la conciencia sobre la alimentación saludable sigue aumentyo, los edulcorantes naturales sin calorías se han convertido en un foco principal de atención de los consumidores. En junio de 2025, se publicó un estudio en la revista internacional Food Chemistry: X systematic
While we are deeply engaged in exploring anti-aging solutions for humans, our furry companions at home are quietly facing health challenges brought on by aging—reduced energy levels, dull coats, y a slower metabo
Have you ever experienced moments like these: walking into a room y forgetting why you went there, struggling to recall a familiar name, or suffering from persistent insomnia after staying up late—followed by day
In today’s global wave of health awareness, “sugar reduction” has become a widely accepted trend. Steviol glycosides, as natural zero-calorie sweeteners, have already entered households worldwide. Howev
Recently, a study published on bioRxiv revealed the metabolic secrets behind the remarkable longevity of centenarians. Led by Boston University, the research conducted metabolomic analyses on 213 participants—
En la actual búsqueda de la salud y la longevidad, el enfoque científico se ha desplazado de los macronutrientes al metabolismo energético celular. Entre muchas moléculas emergentes, el ribósido de nicotinamida (NR) se ha convertido en una estrella emergente en la ciencia de la vida
A medida que la población mundial sigue envejeciendo, abordar el deterioro cognitivo y el deterioro físico relacionados con la edad se ha convertido en un gran desafío científico. En abril de 2025, un estudio pionero se publicó en Frontiers in Phar
Introduction: As time quietly passes, have you noticed your once lively dog becoming slower to respond or experiencing disrupted sleep? Don’t worry — science is bringing new hope! The latest clinical trial h
Global population aging is becoming increasingly pronounced. It is estimated that by 2050, the number of people aged 65 y above will reach 1.6 billion—double the 780 million recorded in 2020. As aging progresses,
¡Un nuevo estudio autorizado está aquí! Un experimento de 2025 realizado por el equipo de la Universidad Northwest A&F, publicado en el Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), revelado con rigor
September 29, 2025 — After nearly three years of pressure from the Natural Products Association (NPA), the U.S. Food y Drug Administration (FDA) has reversed course y confirmed that Beta (β) Nicotinamide M
In recent years, “N-series” anti-aging dietary supplements represented by NMN y NR have continued to gain popularity in markets across Europe, the U.S., Japan, y China. The core mechanism of these product
In the world of nutrition, some substances have existed for over a hundred years but have only recently been recognized for their great value. Ergothioneine (EGT) is such a modest yet precious dietary component. △ Ch
Según las últimas investigaciones publicadas en revistas autorizadas como *Nature Metabolism*, los datos de metabolómica humana muestran cambios dramáticos no lineales entre los 30 y los 50 años. Estos incluyen el metabolismo lipídico imb
Do you often feel exhausted? Struggled with blood sugar issues for years? Or perhaps you’re seeking anti-aging solutions y vibrant health? Today, let’s explore a powerful “energy key” hidden dee
NAD+: The Indispensable 'Cell Fuel' y 'Repairman' NAD+ is a key coenzyme involved in cellular energy metabolism (e.g., converting food into ATP), DNA repair (e.g., activating PARP enzymes), y regulat
In an age where the pursuit of 'frozen age' y 'reverse growth' is on the rise, anti-aging is no longer a distant dream. The core molecule—NAD+ (Nicotinamide Adenine Dinucleotide)—plays a cri
A medida que el interés público por el envejecimiento saludable y la longevidad sigue creciendo, la investigación sobre el metabolismo del NAD⁺ (Dinucleótido de Nicotinamida Adenina) ha ganado un impulso significativo. NMNH (Mononucleótido de Nicotinamida Reducida), la redu
El ginseng, una hierba legendaria en la medicina tradicional, se ha utilizado durante milenios por sus múltiples beneficios para la salud. En el centro de su destreza medicinal están los ginsenósidos, potentes saponinas que han despertado el interés del mod
El ginseng, venerado durante siglos en la medicina tradicional china, es una raíz conocida por sus notables propiedades terapéuticas. En el centro de su eficacia se encuentran los ginsenósidos, un grupo diverso de saponinas consideradas la activa s
Nicotinamide Adenine Dinucleotide Phosphate (NADP), a crucial coenzyme in cellular metabolism, serves as a cornerstone in numerous biochemical reactions. As a derivative of NAD, it adds a phosphate group which enhan
El mundo de la bioquímica está repleto de moléculas que, aunque no siempre están en el punto de mira, desempeñan un papel fundamental en el mantenimiento y regulación de los procesos celulares. Entre ellas, las coenzimas oxidadas destacan por su
En el intrincado mundo de la bioquímica, las coenzimas desempeñan un papel fundamental en la facilitación de numerosas reacciones metabólicas esenciales para la vida. Una de estas coenzimas cruciales es el fosfato de dinucleótidos de nicotinamida adenina (NADP). Esto
En el mundo de los edulcorantes naturales, la stevia ha conquistado un lugar importante gracias a su dulzura excepcional y sus beneficios para la salud. Derivado de las hojas de la planta Stevia rebaudiana, este edulcorante sin calorías h
In the world of dietary substances, every detail matters—from the source of the ingredients to the color of the final product. For those curious about the health benefits of Nicotinamide Mononucleotide Hydrogen (NM
En el cambiante panorama de las sustancias para la salud y el bienestar, la búsqueda de soluciones más eficaces para combatir el envejecimiento y mejorar la salud celular es perpetua. Entre los principales avances está el uso de NAD+ enh
In the expansive world of biochemical research y health preservation, certain compounds emerge as particularly significant due to their potential applications y benefits. One such compound is NMNH, which sta
Nicotinamide adenine dinucleotide hydrogen (NADH) is a lesser-known yet crucial molecule in the biological sciences y various health-related fields. In this blog, we explore the wide-ranging applications of NA
En la búsqueda de mantener la energía y la salud juveniles a medida que envejecemos, la investigación científica sigue aportyo nuevas sustancias que pueden ayudar en esta búsqueda. Uno de los más prometedores es el Beta-Nicotinamida Mononu
In the quest for optimal health y vitality, understying the role of coenzymes in cellular function is paramount. Nicotinamide Adenine Dinucleotide Hydrogen (NADH) is one such coenzyme that plays a critical r
El nicotinamida adenina dinucleótido (NAD+) es una piedra angular de la salud celular, desempeñyo un papel fundamental en la producción de energía y los procesos metabólicos que sostienen la vida. A medida que envejecemos, los niveles de NAD+ disminuyen de forma natural, y el plomo
Energy metabolism is a crucial biological process that involves converting food into the energy needed to power all cellular activities. It is fundamental to maintaining health, vitality, y overall well-being. One
En el ámbito de la salud y el bienestar, mantener una función celular óptima es clave para la vitalidad y longevidad generales. Una molécula central en numerosos procesos biológicos es el Dinucleótido de Nicotinamida Adenina, com
En la búsqueda de vitalidad y longevidad, los avances científicos en torno a la nicotinamida mononucleótido (NMN) han captado la atención de entusiastas de la salud en todo el mundo. BONTAC, líder en innovación bioquímica
En la búsqueda de la salud y la longevidad, los avances científicos a menudo nos llevan a compuestos naturales que pueden mejorar significativamente nuestro bienestar. Uno de esos compuestos que ha captado la atención de la salud y el bienestar
En el sector de la biotecnología, que evoluciona rápidamente, los productos derivados de procesos y organismos biológicos están transformyo industrias desde la sanidad hasta la agricultura. El mercado de productos biotecnológicos es ferozmente competitivo, wi
En el dinámico mundo de la salud y la biotecnología, el rejuvenecimiento celular destaca como un concepto revolucionario, prometiendo una nueva era de salud mejorada, juventud prolongada y mejora de la calidad de vida. Como líder en el glo
In the rapidly evolving lyscape of health y wellness, metabolism-boosting products have emerged as key components in enhancing human health, optimizing metabolic processes, y supporting various bodily functi
Introduction In the realm of animal husbyry, feed additives are necessary as they can not only improve the nutritional value of feed y optimize the internal environment of the rumen, but also enhance
Introduction Nicotinamide adenine dinucleotide (NAD) deficiency has been linked to a range of renal disorders, encompassing conditions such as acute kidney injury, diabetic nephropathy, adenine-triggered kidney diseas
Introduction In response to the escalating global obesity rates, the demy for sugar reduction has reached a critical juncture. As a strategic pivot, the food industry has increasingly incorporated sugar substitutes,
Introduction Parkinson's disease (PD), known as the silent killer, has emerged as the second most common chronic neurodegenerative disease in the world after Alzheimer's disease, affecting
Introduction Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme in cells, a central cofactor of redox reaction y a central regulator of various metabolisms in the human body. It is involved in a
Introduction Spinal cord injury (SCI) can lead to severe impairments in motor, sensory, y autonomic nervous system functions. It has been reported that motor function recovery can be promoted by mediatin
Introduction Chronic cerebral hypoperfusion (CCH) has been identified as one of the initial conditions critical to the development of cognitive impairment, which is tightly associated to the complex neurologic
Introduction Stroke remains the second leading cause of death y the third leading cause of death y disability combined in the world, as reported in 2019 Global Burden of Disease Study. Ischemic stroke
Introduction Myocardial ischemia/reperfusion (MI/R) can damage the heart muscle, which may contribute to further cardiomyocyte death. Following percutaneous coronary intervention therapy, patients with MI/
Introduction According to the report by World Health Organization (WHO) in 2017, depression is the third leading cause of the global disease burden, with over 300 million people suffering from this disease w
Thanks to our unrelenting dedication to creating cutting-edge solutions that push the frontiers of scientific development, BONTAC has long been at the forefront of the biochemical sector. We are excited to present o
Our unshakable dedication to maximizing the potential of traditional Chinese medicine has propelled BONTAC to the forefront of the natural products sector for a considerable amount of time. We are thrilled to presen
Nuestra inquebrantable búsqueda de innovación en BONTAC has always been sparked by our profound grasp of the natural world y its unrealized potential. We are excited to present our ground-breaking solutions today, which are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries y improve lives, we at BONTAC have long been at the forefront of the green biotechnology revolution. We are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries y improve lives, BONTAC has long been at the forefront of the green biotechnology revolution. We are ex
For many years, BONTAC has been acknowledged as a leader in the field of green biotechnology, thanks to our unwavering commitment to creating ground-breaking products y services that have the potential to improve
Because of our unwavering search for products that have the power to genuinely change the lives of our partners y consumers, we at BONTAC have long been at the forefront of cutting-edge green biotechnology solutio
Being deeply aware of the vital role our products play in enabling people to live healthier, more fulfilling lives has always motivated us at BONTAC to innovate. We are pleased to announce our ground-breaking NMNH,
Propelled by an unwavering dedication to innovation y a profound comprehension of the crucial function this coenzyme plays in preserving cellular health y lifespan, BONTAC has been at the forefront of the NAD+ a
At BONTAC, we have always been driven by a relentless pursuit of innovation – a desire to push the boundaries of what is possible in the realm of nutritional supplements y biomedical research. Today, we are thril
En BONTAC, desde hace tiempo nos apasiona la búsqueda de soluciones nutricionales de vanguardia que puedan transformar verdaderamente la salud y el bienestar humanos. Hoy, nos complace poner el foco en uno de los más notables
En BONTAC, siempre hemos estado a la vanguardia de la investigación nutracéutica de vanguardia, dedicados a descubrir los compuestos más notables y transformadores que la naturaleza puede ofrecer. Hoy estamos encantados de presentarte ou
For many years, BONTAC has been at the forefront of innovative biopharmaceutical developments, committed to maximizing the life-changing potential of nature's most extraordinary substances. We are excited to pre
En BONTAC, llevamos mucho tiempo a la vanguardia de la innovación en el ámbito biofarmacéutico, dedicados a aprovechar el poder de los descubrimientos científicos de vanguardia para mejorar la vida de quienes servimos. Hoy, nosotros
En BONTAC, nos impulsa un compromiso profundo para empoderar a las personas con las herramientas que necesitan para alcanzar una salud y un bienestar óptimos. Como líderes del sector en el ámbito de la biotecnología, nos hemos dedicado a nosotros mismos
En BONTAC, nuestra misión es empoderar a las personas con las herramientas necesarias para alcanzar una salud y bienestar óptimos. Como pioneros en el ámbito de la biotecnología, nos hemos dedicado a descubrir el profundo beneficio
En BONTAC, estamos profundamente comprometidos con avanzar en las fronteras de la salud y el bienestar humanos. Como innovador líder en el campo de la biotecnología, nos hemos centrado en aprovechar el increíble potencial de Beta-Nicoti
As a leading player in the world of biotechnology, BONTAC is at the forefront of driving innovation y transforming the industry. Our unwavering commitment to scientific excellence y our deep understying of the
En BONTAC, estamos impulsados por una búsqueda incansable de innovación y un profundo compromiso con la mejora de la vida de quienes servimos. Como líderes en el ámbito de la salud celular y el rejuvenecimiento, nos complace presentar a nuestros
En BONTAC, estamos a la vanguardia de la industria de productos que aceleran el metabolismo, impulsados por nuestro compromiso inquebrantable con la innovación y la búsqueda de la excelencia científica. Nuestro enfoque en desarrollar soluciones de vanguardia h
Introduction With changes in lifestyles y dietary structure, hyperuricemia shows an increasing prevalence year by year, which may become the second largest metabolic disease after diabetes mellitus, a
Introduction Steviol glycosides are secondary metabolites obtained by extracting y isolating stevia from the herbaceous plant Stevia rebaudiana of the Asteraceae family, with a high degree of sweetness
NAD is an abbreviation for nicotinamide adenine dinucleotide, which is a naturally occurring coenzyme (a substance that works with enzymes) found in our bodies. It helps cells produce energy. However, as we age, NAD
Introduction According to the report of International Agency for Research on Cancer (IARC), there are 19.3 million new cases of malignant tumors y 10 million deaths worldwide in 2020. Malignant tumors have overtaken
Introduction Elderly individuals are at a significantly higher risk for peripheral artery disease (PAD), a common vascular disorder. As the global population ages rapidly, the number of PAD cases is projected to rise
Introduction Diabetic kidney disease (DKD) has emerged as one of the primary cause of mortality among the patients with end-stage renal disease such as renal failure, accounting for 30-50% of chronic renal failure cas
Introduction Nicotinamide adenine dinucleotide (NAD+) metabolism is essential for maintaining normal physiological activities, y the decreased NAD+ level is related to various pathologies such as cardiac dis
Introduction Targeting the autophagy-NAD axis has been reported be a viable therapeutic strategy for Niemann-Pick type C1 (NPC1) disease. The study suggests that both pharmacological rescue of autophagy deficiency y
Introduction Apical periodontitis, an inflammatory disease affecting tooth apex tissues, is triggered by oral pathogens infecting the root canal. One of the main reason for endodontic treatment failure is Enterococcus
Introduction Amoebiasis has emerged as the third most common cause of death by parasites worldwide after malaria y schistosomiasis infections. According to the report of World Health Organization, over 40 milli
Introduction Disturbance in hepatic NAD+ metabolism has been manifested as a key factor in the initiation y progression of nonalcoholic fatty liver disease (NAFLD), one of the most co
Introduction According to the 2017 Commission on Traumatic Brain Injury (TBI), TBI remains one of the top three causes of injury-related death y disability up to 2030. There are 50~60
Introduction In clinical settings, doxorubicin (DOX) is an effective broad-spectrum anti-cancer drug in chemotherapy for various tumors, including hematological malignancies y solid tumors such as leu
Introduction Cigarettes containing nicotine (Nic) y sugar-sweetened beverages (SSBs) with high fructose corn syrup (HFCS) have been uncovered to induce hepatic steatosis, which are the risk factors for the developme
Introduction Acute promyelocytic leukemia (APL), the M3 type of acute myeloid leukemia (AML), typically relies on all-trans retinoic acid (ATRA) as its primary treatment. While APL patients treated with
Introduction Recent research unveils that hepatic insulin resistance (IR) y steatosis in obesity have a strong association with endoplasmic reticulum (ER)-mitochondria miscommunication. Notably,
Aging is an undeniable reality of life. It is a known fact that with increasing age, different body functions tend to decline. While we may not completely stop this decline, we can slow it down with pure NMN po
Introduction In the presence of oxygen, tumors produce adenosine triphosphate (ATP) through glycolysis instead of mitochondrial oxidative phosphorylation, a phenomenon known as the “Warburg effect”. Aerobi
Introduction Age-related macular degeneration (AMD) has become one of the leading cause of low vision y even blindness in the elderly, especially in those above 50. In 2020, approximately 1.8 million people aged ove
Introduction Natural products, including single components or extracts of herbal medicines, have the features of good efficacy y low toxicity when used in tumor treatment. They have unique advantages in treating dis
Introduction Reproductive dysfunction is frequent in female suffering from type 1 diabetes (T1D), up to 40% of whom will develop a variety of reproductive dysfunctions throughout their lives. T1D patients often ha
In today's health y anti-aging fields, NMN (nicotinamide mononucleotide) has attracted a lot of attention. As an important cellular coenzyme, NMN plays a key role in maintaining cell health y delaying the aging p
Introduction Ginsenósido Rg3 (Rg3) holds great promise as a potential drug for preventing scar formation, but it is often difficult for it to work alone due to its poor water solubility y low bioavail
Introduction Lead (Pb) contamination in aquatic environments poses a significant threat to the health y well-being of aquatic organisms, including fish species. There is rising popularity of prebiotics y probi
Elevating Wellness: BONTAC's NMN Powder Offerings As we delve into the realm of health y wellness, the spotlight shines brightly on NMN powder, a powerful supplement embraced by many for its potential benefits.
Innovating Solutions: BONTAC's Biotechnology Product Offerings In the ever-evolving lyscape of biotechnology products, BONTAC remains a trailblazer in providing cutting-edge solutions that drive innovation
Revolutionizing Biotechnical Research: BONTAC's Trailblazing Discoveries In the dynamic realm of biotechnical research, BONTAC stys at the forefront of innovation, dedicated to driving progress y breakthr
Elevating Health with BONTAC's Cutting-Edge Longevity Supplements In the realm of health y wellness, the demy for high-quality metabolism-boosting supplements continues to rise. At BONTAC, we recognize the c
Introduction It has been reported that infection with Gram-negative bacteria can disrupt the osteogenic differentiation. Notably, nicotinamide mononucleotide (NMN) protects against osteogenesis from inflammat
Pioneering Discoveries: BONTAC's Innovations in Biotechnical Research In the dynamic realm of biotechnical research, BONTAC stys at the forefront of innovation, dedicated to driving progress y breakthroug
Nutrir el bienestar: BONTAC como proveedor líder de materias primas de suplementos As a prominent raw material supplier of supplements, BONTAC is dedicated to developing y delivering premium products that promote he
Unleash Vitality y Renewal: BONTAC's Cutting-edge Cellular Rejuvenation Solutions Cellular Rejuvenation plays a vital role in enhancing vitality y promoting overall wellness. At BONTAC, we are dedicated t
Introduction Hepatocellular carcinoma (HCC) is hypervascular solid tumor with rapid deterioration, poor overall prognosis y a high recurrence rate, accounting for 90% of primary liver cancers, which ha
Mejorar la salud: Materias Primas Avanzadas de BONTAC para suplementos celulares In today's fast-paced world, the quest for optimal health y wellness has led to a surge in the demy for high-quality cellular
Powering Health y Vitality: BONTAC's Metabolism-boosting Product Portfolio In the dynamic lyscape of health y wellness, the demy for cutting-edge metabolism-boosting products continues to
Unlocking the Power of Metabolism-Boosting Supplements: A Guide by BONTAC In the realm of health y wellness, the demy for high-quality metabolism-boosting supplements is steadily rising. At BONTAC,
Introduction Artificial insemination with chilled ram semen is commonly used method in livestock industry. But storing sperm in chilled conditions may cause changes in sperm membrane function y structure, y
Introduction In light of a statistics report by World Health Organization (WHO), there are 18 million people suffering from rheumatoid arthritis (RA) worldwide in 2019, where the prevalence of female is 2.5 times
Introduction Glaucoma is regarded as the second dominant cause of blindness across the world. With the amounting number y proportion of elderly people, it is estimated that 111.8 million people will have glaucom
Introduction Triocresyl phosphate (TOCP) is widely used in the realm of industry y agriculture in the last century. However, it is subsequently banned due to the increasing understying of its toxicity. In
Introduction Cardiovascular diseases (CVD) poses huge economic burden y great threat to the life of patients, even surpassing Alzheimer's disease y diabetes. 17.9 million people in the world
Introduction Myocardial ischemia-reperfusion (I/R) injury has emerged as an urgent clinical issue that may offset the benefits of reperfusion therapy y even worsen the prognosis of acute myocardial infarction, a
.two-side{ text-align: justify; display: flex; justify-content: space-between; } Introduction The crucial parts of nicotinamide adenine dinucleotide (NAD+) y its metabolites in aging a
Introduction Ginsenósido Rh2 nanoliposome formulation has been proved to effectively target y deliver drugs to the tumor site, with less side effects y higher treatment efficiency, holding great promise in the
Introduction Replenishing nicotinamide mononucleotide (NMN) to raise the availability of nicotinamide adenine dinucleotide (NAD+) has been deemed as effective approach to prevent neurodegeneration in aging y pat
Introduction Rare ginsenoside Rg3, an active extract from Panax ginseng, is reported to possess a wide range of pharmacological properties including anti-angiogenesis y anti-cancer, with high lipophilicity (esti
Introduction Wound healing is a sophisticated process responding to tissue damage, which is associated with numbers of interaction of various cell types, cytokines, growth factors, y other molecules. Strikingly,
Introduction Diabetes is one of the dominant causes of death y disability worldwide, greatly affecting the life quality of patients. According to the latest data on diabetes released by the Lancet (GBD Study 202
Introduction Intervertebral disc degeneration (IDD) is a frequently seen orthopedic disease, which is accompanied with excessive apoptosis of nucleus pulposus cells (NPCs) y degeneration of extracellular ma
Introduction Ginsenósido Rg3 is Panaxanediol type tetracyclic triterpenoid saponin monomer extracted from the root of Panax ginseng, which has a wide range of pharmacological effects including anti-tumor, neuroprotect
Introduction The gut is a diverse y dynamic microbiotic system. There are about 100 trillion microorganisms in the gut, which is mainly composed of anaerobic, partially anaerobic, y aerobic bacteria. In the pr
Introduction Mar 4th is determined as the World Obesity Day. World Obesity Federation, UNICEF y WHO have hosted a global youth-led webinar to talk about obesity & youth. The obesity crisis has gradually attr
Introduction Nicotinamide mononucleotide (NMN), one precursor of nicotinamide adenine dinucleotide (NAD+), has been ascertained to be implicated with multiple biological processes such as cellular redox regulation y
Introduction Alpers' disease is both a neurodegenerative disorder y a metabolic disorder, which is tightly linked to mitochondrial dysfunction y mutations in the catalytic subunit of polymerase
Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen y an electron donor, which participates in diverse physiological processes such as protein synthesis, DNA repair,
Introduction Ginsenósido Rh2, one protopanaxadiol (PPD)-type rare ginsenoside in Panax ginseng, is uncovered to possibly have broad-spectrum pharmacological activity in diversified tumors. It is utili
Introduction Solute carrier family 25 member 51 (SLC25A51) is perceived as a mammalian transporter, which is capable of importing oxidized nicotinamide adenine dinucleotide (NAD+) into mitochondrial matrix. Remark
Introduction Oxidized form of nicotinamide adenine dinucleotide (NAD+) y its precursor nicotinamide mononucleotide (NMN) have been uncovered to restore DNA repair y prevent cancer progression via the deleted i
1. Introduction Disrupted nicotinamide adenine dinucleotide (NAD+) metabolism is increasingly deemed to be one of risk factor for amendable cardiovascular disorders. A substantial evidence has mirrored that res
1. Introduction Rare ginsenosides, a group of dammarane triterpenoids that exist in low natural abundance, fuels a high concern from scholars recently, showing great potential as shining components in drugs y nu
1. Introduction Nicotinamide adenine dinucleotide (NAD) has been unveiled to be essential for embryonic development. Patients with genetic variants in the NAD+ de novo synthesis pathway often have congen
1. Introduction The gut microbiota has long been regarded as one of the key elements contributing to the regulation of host health. Any changes in the composition or quality of the gut microbiota may have physiolo
1. Introduction Nicotinamide adenine dinucleotide (NAD) compartmentalized in adipocytes can modulate adipocyte differentiation y gene expression, in addition to controlling glucose metabolism. White adipose tiss
1. Introduction Nicotinamide mononucleotide (NMN) supplementation has been suggested to hamper the inflammatory responses via restoring NAD+ level y downregulating the expression of C
1. Introduction Age-related NAD+ depletion affects physiological functions y contributes to various aging-related diseases. NAD+ precursors can significantly elevate NAD+ level in murine tissues, effectivel
1. Introduction In mammalian cells, the majority of NAD+ is produced from metabolites entering the NAD+ salvage pathway. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme of the salvage
NMNH, también conocida como nicotinamida mononucleótido hidratado, es una coenzima vital que se encuentra en todas las células vivas. Desempeña un papel crucial en el metabolismo celular, la producción de energía y varios procesos biosintéticos. N de alta pureza
En el ámbito de los suplementos para la salud, el NADH destaca como una coenzima crucial implicada en el metabolismo celular. Su importancia para mantener los niveles de energía y apoyar el bienestar general lo ha convertido en un ingrediente muy valorado para
1. Introduction Nicotinamide Mononucleotide (NMN) has been deemed as a functional nutrient for improving human intestinal health. In this study, an in vitro simulated digestion model
1. Introduction Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects the motion-related nerve cells in the brain y spinal cord. The disease is featured by the d
1.Introduction A series of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease y Huntington's disease, are accompanied with bioenergetic maladaptations y axonopathy wi
1. Introduction Diabetic peripheral neuropathy (DPN) is one of the most frequent complications of diabetes, ans also a major cause of foot ulcers, disability, y eventual amputation. With the prolongation of the
1.Introduction Mitochondria, a type of highly plastic organelle, can maintain a relatively stable dynamic equilibrium state towards the morphology, structure, quantity, volume, quality, y function
1. Introduction Atherosclerosis is a chronic progressive inflammatory disease, which is featured by the accumulation of lipids in the intima of the arteries with yellow appearance. This disease
1. Introduction Mitochondria are the center of energy metabolism in cardiomyocytes, which are necessary for maintaining normal myocardial contractility y cardiac function. Typically, the de
1. Introduction According to the 2020 report of World Health Organization (WHO), there are approximately 2.3 million cases with breast cancer worldwide. Breast cancer has emerged as one of the
1.Introduction The senescence in mammals is generally concomitant with the dysregulation of intestinal homeostasis y the accumulation of mitochondrial DNA (mtDNA) mutations. High-burden mtDNA mutations lead to N
1. Introduction At present, vaccine is the preferred option for the prevention of foot-y-mouth disease (FMD), for which the adjuvant is essential due to its strong role in boosting immune response associated wi
1. Introduction Acute lung injury comprises a uniform response of the lung to inflammatory or chemical insults which is commonly caused by systemic illness including sepsis or trauma, infection with pathogens, y tox
1. Introduction Gastric cancer (GC) represents a global health-care challenge, which is the fifth most common cancer y the fourth leading cause of cancer death across the world in 2020, with a significant
1. Introduction Supplementation of nicotinamide mononucleotide (NMN) to upregulate the level of nicotinamide adenine dinucleotide (NAD+) has been unveiled to be a promising anti-aging intervention. However, it is
1.Introduction Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), also known as reduced coenzyme II, is a critical cofactor in cellular antioxidant systems y lipid synthesis, which links insulin
1. Introduction Dengue fever is an acute infectious disease caused by the Dengue virus through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito, with the main symptoms such as hi
1. Introduction The NAD precursor nicotinamide mononucleotide (NMN) shows a beneficial effect on ageing, yet excessive NMN accumulation may lead to axon degeneration. How to make the anti-ageing
1 Introduction Nicotinamide riboside (NR), a derivative of vitamin B3, is a new type of bioactive substance, which can be generated by binding a carbohydrate molecular ribose with nicotinamide (a
1. Introduction Heart failure is a serious condition in the development of cardiovascular disease. In particular, diastolic heart failure, as one of the most common manifestations of heart failure in
1. Introduction Ginseng has always been highly perceived as a valuable traditional Chinese medicine in China. Currently, much attention also has been paid to ginsenosides, the main active ingredients extracted from g
1. Introduction On July 2023, the World Health Organization (WHO) has classified the soda sweetener aspartame as a possible carcinogen, but said that aspartame is safe to consume with
Myocardial mitochondria are primary sites of myocardial energy metabolism. Mitochondrial disorders are associated with various cardiac diseases. Mitochondrial translation defects cause not only mitochondrial
La reacción inflamatoria y la ruptura de la barrera cutánea causada por el estrés oxidativo desempeñan un papel crucial en el proceso de la dermatitis atópica (EA). Los niveles de peroxidación lipídica suelen ser más altos en pacientes con EA, mientras que los antio
La vitamina D y la B3 (niacina) podrían ayudar a la activación inmunitaria y a la reconstitución de las células T CD4+ en los INR. El NAD, vital para la función celular, disminuye con la edad, vinculándose a diversas enfermedades. Los promotores de NAD como NMN, NR y NAM muestran el baile de graduación
Sepsis, marked by dysregulated infection response, lacks effective treatment. NAD+'s role in inflammation remains unclear. NAD+ transport challenges limit its therapeutic impact. Novel NAD+-loaded nanoparticles (NPs)
En el diagnóstico clínico, las enzimas son biocatalizadores importantes y desempeñan un papel clave en muchas reacciones bioquímicas. Estas enzimas requieren coenzimas, lo que llamamos Coenzimas de Reactivos Diagnósticos, para desempeñar sus funciones.
La barrera hematoencefálica (BBB) es un componente fundamental del sistema nervioso central que regula el intercambio de moléculas entre el cerebro y el torrente sanguíneo. Los cambios relacionados con la edad en la BBB pueden provocar un aumento por
La demencia vascular es uno de los síndromes graves e irreversibles de deterioro de la inteligencia adquirida causados por una serie de enfermedades cerebrovasculares. La citicolina es el derivado del lado nucleo, que no solo puede exhi
In the quest for a healthier lifestyle, the sweetener debate continues to rage. While sugar has long been the default choice, its adverse health effects have prompted a search for alternatives. One such swe
The nicotinamide adenine dinucleotide (NAD+ )/reduced NAD+ (NADH) y NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular redox homeostasis y for modulating numerous biologic
La hipertensión es una preocupación importante de salud global, vinculada a millones de muertes por problemas cardiovasculares. Implica disfunción endotelial y rigidez arterial, lo que contribuye a enfermedades ateroscleróticas. Mejora del VA
Las dietas altas en azúcar han provocado un aumento de la prevalencia de diversas enfermedades crónicas, incluyendo obesidad, diabetes, enfermedades cardiovasculares e hipertensión, lo que supone una importante preocupación de salud pública a nivel mundial. Stevia Rebaudiosid
CFS is a disorder of unknown etiology, consisting of prolonged, debilitating fatigue, y a multitude of symptoms including neurocognitive dysfunction, flu-like symptoms, myalgia, weakness, arthralgia, low-grade fev
El alcohol es un tipo de sustancia psicoactiva que se ha utilizado comúnmente en varias culturas durante siglos. El consumo de alcohol es la principal causa de daño hepático agudo y enfermedad hepática crónica. El alcoholismo puede acelerar al hombre
La Stevia (Stevia rebaudiana Bertoni), un arbusto perenne de la familia Compositae, se cultiva en muchas regiones del mundo. Es famosa por su dulzura, que se debe a la presencia de glucósidos esteviol, que tienen 1
El esteviósido es un edulcorante natural derivado de la planta de stevia. Tiene una alta intensidad de dulzura y un contenido calórico bajo, lo que lo hace atractivo para diabéticos y otras personas con dietas controladas en carbohidratos. Sin embargo, stevios
Highlight: In chronic HBV infection elevated ROS production is associated to high DNA damage in HBV-specific CD8 T cells - Response to DNA damage is dysfunctional - Up-regulation of CD38 y persistent activatio
In the pass decades days, the Open AI y the amazing founder behind AI application both captured attention world widely. But recently, as MIT Technology Review reported, the OpenAI CEO Sam Altman has turned ou
NMNH potencia potentemente el NAD+ y suprime la glucólisis, el ciclo del TCA y el crecimiento celular NAD+ is essential for biological processes such as metabolism y DNA repair, y its decline is associated with age-related diseas
Ginsenósidos on Cancer y Related Clinical Studies Cancer is a leading cause of death globally, y its treatment often involves a combination of surgery, chemotherapy, y radiation therapy. These treatm
Ingeniería enzimática acoplada al crecimiento mediante manipulación de la regeneración de cofactores redox An increasingly wide range of chemicals are now being produced from renewable feedstocks through biotechnological means. Biopro
Supervision Policies for NMN in Japan, China, America, Australia y Canada The mainstream researches of NMN have been conducted since a decade years ago. The United States had already carried out its commerciali
Collections of Clinical Trails on NMN Oral Administation NMN, as one of NAD+ booster family critical members, become increasingly popular on the market in the filed of health pomoting. And to date, there are
Con el relajamiento de las políticas de control epidémico en todo el mundo, los residentes de China, India, Malasia, Japón y Singapur han sufrido una escasez de medicamentos en mayor o menor medida. Pero, por otro lado, el tipo de medicamentos que tienen
Attention! The Cambridge University Researchers Found Ursodeoxycholic Acid (UDCA) Can Prevent y Treat Covid-19 The International academic journal Nature published an article titled FXR inhibition may protect from SARS
El 10 de agosto de 2021, investigadores de la Universidad de Ciencia y Tecnología de Shanghái publicaron un artículo titulado El suplemento NAD+ potencia la función destructiva del tumor al rescatar transcripciones defectuosas de NAMPT mediadas por TUBBY
